Maternal and Newborn Health Study

The PRISMA Maternal and Newborn Health study is a prospective, open cohort study with a planned recruitment of about 20,000 pregnant women over three years across six research sites in two South Asian and three sub-Saharan African countries. Participants are pregnant women identified through active house-to-house and facility-based surveillance at less than 20 weeks gestation, as determined by ultrasound. High-quality data will be collected over 12 study visits: five antenatal care (ANC) visits, labor and delivery, and six postnatal care (PNC) visits up to one year postpartum. A total of 34 standardized maternal and fetal/infant outcomes will be assessed. The primary analysis will estimate the burden of adverse outcomes and examine the risk factors to inform potential intervention strategies. Data from this effort will also be used to develop normative values for pregnant and postpartum women, as well as predictive models to evaluate pregnancy risk.